Dried, sliced astragalus sold in Chinese herb shops and supermarkets.
WebMD: July 7, 2010 — Aging cells greatly increase your risk of deadly cancer — even if you’re still relatively young. Cells stay young as long as they are able to repair their own DNA. That’s up to telomeres, the proteins at the end of each chromosome. But every time a cell reproduces, its telomeres get shorter. A startling new study now shows that people who accumulate a lot of cells with short telomeres have greatly increased risk of fatal cancers. What increases telomere strand length–thereby protecting DNA and preventing cancers? Astragalus. Simmer 8 slices in a quart of water for 30 minutes and drink it between meals for improved energy and immunity. Here are three important studies.
Mandy M.Y. Tin, Chi-Hin Cho1, Kelvin Chan2, Anthony E. James3 and Joshua K.S. Ko*Pharmacology and Toxicology Laboratory, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong,
1 Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
2 School of Applied Sciences, University of Wolverhampton, Wolverhampton WV1 1SB, UK
3 Laboratory Animal Services Center, The Chinese University of Hong Kong, China
* To whom correspondence should be addressed. Tel: +852 3411 2907; Fax: +852 3411 2461; Email: firstname.lastname@example.org
Astragalus memebranaceus is used as immunomodulating agent in treating immunodeficiency diseases and to alleviate the adverse effects of chemotherapeutic drugs. In recent years, it has been proposed that Astragalus may possess anti-tumorigenic potential in certain cancer cell types. In this study, the anti-carcinogenic effects of Astragalus saponin extract were investigated in HT-29 human colon cancer cells and tumor xenograft. Our findings have shown that Astragalus saponins (AST) inhibit cell proliferation through accumulation in S phase and G2/M arrest, with concomitant suppression of p21 expression and inhibition of cyclin-dependent kinase activity. Besides, AST promotes apoptosis in HT-29 cells through caspase 3 activation and poly(ADP-ribose) polymerase cleavage, which is indicated by DNA fragmentation and nuclear chromatin condensation. Nevertheless, we also demonstrate the anti-tumorigenic effects of AST in vivo, of which the reduction of tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable with that produced by the conventional chemotherapeutic drug 5-fluorouracil (5-FU). In addition, the side effects (body weight drop and mortality) associated with the drug combo 5-FU and oxaliplatin are not induced by AST. These results indicate that AST could be an effective chemotherapeutic agent in colon cancer treatment, which might also be used as an adjuvant in combination with other orthodox chemotherapeutic drugs to reduce the side effects of the latter compounds.
Abbreviations: dUTP, 2′-deoxyuridine 5′-triphosphate; PARP, poly(ADP-ribose) polymerase; PCNA, proliferating cell nuclear antigen; TdT, terminal deoxynucleotidyl transferase; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP in situ nick-end labeling. . . Received August 21, 2006; revised October 16, 2006; accepted November 19, 2006.
Wang Deqing;Shen Wenmei;Tian Yaping;Jiang Cien (Department of Biochemistry, General Hospital of PLA, Beijing 100853, China).
The protective effect of total flavonoids Astragalus (TFA), one of the natural anti-oxide agent isolated from Astragalus monghlious, on DNA strand breaks induced by the hydrogen peroxide and gamma rays has been investigated with the fluorometry assay of DNA unwinding (FADU). The results showed that the TFA has different degree of protective effect on DNA strand breaks caused by hydrogen peroxide and gamma rays respectively. It also showed some protective effect on DNA strand breaks induced by these two damage factors,when the concentration of TFA were 0.4 g/Land 0. 6 g/L, respectively. When its concentrations were increased to 0. 8 g/L and I .2 g/L,TFA could effectively protect DNA from hydrogen peroxide and gamma rays damages. Compared the protective effect of TFA on DNA strand breaks induced by hydrogen peroxide and gamma rays, the former was better. The protective mechanism of TFA on DNA strand break could be related to savenging free radicals.
ZHANG Pengxia,LIANG Yunxia,TANG Xiaoli,et al. Author′s address School of Basic Medical Science of Jiamusi University, Heilongjiang Jiamusi, 154007
Objective: To observe effects of astragalus root on the changes of the activity of SOD, the expression of P16 and the length of telomere. Method: The serum of rabbits which were filled with water decoction of astragalus root and then cultured human dermal fibroblasts in DMEM contained with astragalus root serum was collected. The activity of SOD was determined by colorimetric method,the expression of P16 by RT-PCR and the length of telomere by TRP-Southern blot. Result: Compared with those in the control group, the activity of SOD increased, the expression of P16 depressed,the length of telomere lengthened. Conclusion: Astragalus root serum can postpone senescence by increasing the activity of SOD,depressing the expression of P16 and inhibiting the shortening of telomere.
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